Covid-19: Razvoj vakcine, imunitet i primena medikamenata

[vememah]

 

[precog]

nista bez rezultata klinickih studija.

[vememah]

Iz teksta:

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“It’s one thing not to have benefit, but this shows distinct harm,” said Eric Topol, a cardiologist and director of the Scripps Research Translational Institute. “If there was ever hope for this drug, this is the death of it.”

 

 

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Eric Jeffrey Topol (born 1954) is an American cardiologist, scientist, and author. He is the Founder and Director of the Scripps Research Translational Institute[1], a Professor of Molecular Medicine at The Scripps Research Institute, and a Senior Consultant at the Division of Cardiovascular Diseases at Scripps Clinic in La Jolla, California. He is editor-in-chief of Medscape and theheart.org. He has published 3 bestseller books on the future of medicine.[2]The Creative Destruction of Medicine (2010), The Patient Will See You Now (2015), and Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again (2019). He was also commissioned by the UK 2018-2019 to lead planning for the National Health Service's future workforce, integrating genomics, digital medicine, and artificial intelligence.

...

As a researcher, Topol has published over 1,200 peer-reviewed articles, with more than 270,000 citations, h-index 228, elected to the National Academy of Medicine, and is one of the top 10 most cited researchers in medicine.

https://en.wikipedia.org/wiki/Eric_Topol

[precog]

lek je na trzistu vise decenija, znaju se nuspojave. post hoc studije su nepouzdane posto ne kontrolises/ne poznajes sve varijable. ne znamo sta su jos sve uzimali/dobijali pacijenti, njihovu istoriju bolesti, da li imaju neko hronicno stanje itd. 

za pouzdani odgovor je potrebna klinicka studija,  vise njih se trenutno rade. ono sto je korisno je da ce sad da bude zaustavljena offlabel upotreba ovog leka do konacne potvrde. 

u normalnim uslovima hcq se ne bi ni u ludilu prepisivao bez potvrde dejstva i odobrenja za koriscenje u c19 tretmanu.

[vememah]

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"As far as I know, four of our fourteen vaccines will soon be in the clinical trial stage, within 4 to 5 months. All the 14 are right now at the pre-clinical trial stage."

However, the [Indian Health] Minister [Harsh Vardhan] cautioned that it is too early to expect any vaccine against the disease because there is a long due procedure involved in its development. "It will take minimum one year for the development of any vaccine even if it is developed earliest. Therefore use social distancing, masks and follow hand and physical hygiene -- the biggest safeguard against the disease -- till any vaccine or cure is found," said the Minister.

 

https://zeenews.india.com/india/four-coronavirus-covid-19-vaccines-may-soon-enter-clinical-trial-stage-in-india-harsh-vardhan-2285885.html

[Roger Sanchez]

Nije još peer-reviewed, ali dovoljno je dobroćudno zanimljivo da se podijeli

 

 

[pasha]

Coronavirus uses same strategy as HIV to dodge immune response, Chinese study finds

• Both viruses remove marker molecules on surface of an infected cell that are used to identify invaders, according to Chinese researchers
• This commonality could mean Sars-CoV-2 may be around for some time, they say

The novel coronavirus uses the same strategy to evade attack from the human immune system as HIV, according to a new study by Chinese scientists.

Both viruses remove marker molecules on the surface of an infected cell that are used by the immune system to identify invaders, the researchers said in a non-peer reviewed paper posted on preprint website bioRxiv.org on Sunday. They warned that this commonality could mean Sars-CoV-2, the clinical name for the virus, could be around for some time, like HIV.

Virologist Zhang Hui and a team from Sun Yat-sen University in Guangzhou also said their discovery added weight to clinical observations that the coronavirus was showing “some characteristics of viruses causing chronic infection”.

Their research involved collecting killer T cells from five patients who had recently recovered from Covid-19, the disease caused by the virus. Those immune cells are generated by people after they are infected with Sars-CoV-2 – their job is to find and destroy the virus.

But the killer T cells used in the study were not effective at eliminating the virus in infected cells. When the scientists took a closer look they found that a molecule known as major histocompatibility complex, or MHC, was missing.

 

The molecule is an identification tag usually present in the membrane of a healthy cell, or in sick cells infected by other coronaviruses such as severe acute respiratory syndrome, or Sars. It changes with infections, alerting the immune system whether a cell is healthy or infected by a virus.

HIV uses the same strategy – MHC molecules are also absent in cells infected with that virus.

“In contrast, Sars does not make use of this function,” Zhang said.

Another study by researchers in New York and Shanghai also found that Sars-CoV-2 could kill T cells. The discovery came after autopsies in China found immune system destruction similar to that caused by Aids.

Four decades after HIV – a virus that attacks the immune system – emerged, it has killed about 32 million people globally, according to the World Health Organisation, and there is still no vaccine or drug that can completely cure the disease.

 

https://www.scmp.com/news/china/science/article/3086177/coronavirus-uses-same-strategy-hiv-dodge-immune-response-chinese

 

[Kelt]

9 hours ago, Roger Sanchez said:

Nije još peer-reviewed, ali dovoljno je dobroćudno zanimljivo da se podijeli

 

 

da ovo neko predlozi kod nas verovatno bi mu rekli da je lud

[Filozof manijak]

Postavih pitanje na drugoj temi; kako se meri nivo corona virusa u gradskoj kanalizaciji?!?

[Kelt]

pa, sve razvijene zemlje imaju treatment plant gde odlazi fekalna kanalizacija, za razliku od nas koji to ispuštamo u reke. Iz sadržaja za tretman se uzme uzorak, pripremi se, umnoži se ...

[Filozof manijak]

mene kao laika onda zanima koliko je validna informacija da se virus prenosi samo kapljično, ako je toliko prisutan u ljudskim fekalijama i izlučevinama?
Jel to znači da se može preneti na isti načina kao npr. hepatitis?

Možda postavljam glupa pitanja, onda se izvinjavam

 

[Kelt]

evo šta kaže CDC

 

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The virus that causes COVID-19 has been found in untreated wastewater. Researchers do not know whether this virus can cause disease if a person is exposed to untreated wastewater or sewerage systems. 

 

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The virus that causes COVID-19 has been found in the feces of some patients diagnosed with COVID-19. However, it is unclear whether the virus found in feces may be capable of causing COVID-19. There has not been any confirmed report of the virus spreading from feces to a person. Scientists also do not know how much risk there is that the virus could be spread from the feces of an infected person to another person. 

 

 

[vememah]

1 hour ago, Filozof manijak said:

kako se meri nivo corona virusa u gradskoj kanalizaciji?!?

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When municipal raw wastewater discharges into treatment facilities, solids are settled and collected into a matrix called (primary) sewage sludge, which has been shown to contain a broad diversity of human viruses including commonly circulating coronavirus strains. Primary sludge provides a well-mixed and concentrated sample that may be advantageous for monitoring SARS-CoV-2. 

https://www.medrxiv.org/content/10.1101/2020.05.19.20105999v1.full.pdf

[Filozof manijak]

hvala na objašnjenju

[Shitgenstein]

BCG Against Coronavirus: Less Hype And More Evidence, Please