Covid-19: Razvoj vakcine, imunitet i primena medikamenata

[Apollo Creed]

Jbg

[TdEII]

On 29.6.2020. at 21:02, TdEII said:

Nego, ovo otvoreno pismo  je zanimljivo, formiranje cene Ramdesivir-a (An Open Letter from Daniel O’Day, Chairman & CEO, Gilead Sciences). Ukratko:

• for governments of developed countries of $390 per vial. Based on current treatment patterns, the vast majority of patients are expected to receive a 5-day treatment course using 6 vials of remdesivir, which equates to $2,340 per patient.
• In the U.S., the same government price of $390 per vial will apply. …for U.S. private insurance companies, will be $520 per vial.
• In the developing world, … we have entered into agreements with generic manufacturers to deliver treatment at a substantially lower cost.

 

Po vesti od juče, ispada da je potpuno nebitno kolika je cena za sve razvijene zemlje. SAD su kupile 100% julske, 90% avgustovske i 90% septembarske proizvodnje Ramdesivira. Za sad. 

 

Pozdravljam potez Jenkija, red bi bio da na sebi i sopstvenom reprezentativnom uzorku isprobaju novi lek, pa da jave sve neželjene pojave. Nama ostalima želim da nastavimo sa ovim čime smo i do sad lečili ljude. I da sa malo ubrzamo istraživanje i razvoj i drugih lekova. 

 

Ako Gilead uskoro ne sklopi sporazume za generike, zemlje u razvoju su takođe izvisile za baš ovaj čudesni lek. Ispašće da je ovo bilo one-hit wonder...

[TdEII]

Food for thought -

 

A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2 - idemo ka malo realističnijim modeliranjem 

 

Abstract: Despite various levels of preventive measures, in 2020 many countries have suffered severely from the coronavirus 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. We show that population heterogeneity can significantly impact disease-induced immunity as the proportion infected in groups with the highest contact rates is greater than in groups with low contact rates. We estimate that if R0 = 2.5 in an age-structured community with mixing rates fitted to social activity then the disease-induced herd immunity level can be around 43%, which is substantially less than the classical herd immunity level of 60% obtained through homogeneous immunization of the population. Our estimates should be interpreted as an illustration of how population heterogeneity affects herd immunity, rather than an exact value or even a best estimate.

 

Vredi pročitati rad, dobar, jasno definisanja ograničenja i zanimljivi rezultati. Npr. 2 talas je izražen samo u slučajevima kad su uvedene vrlo restriktivne mere lockdown, koje su podignute PRE kraja (Fig. 1)

Iz rada, tabele

 

 

Edited July 2, 2020 by TdEII
Zaboravljena opaska o Fig. 1

[Ros]

remdesivir dobio dozvolu za koriscenje u EU

[Aleksija]

On 2.7.2020. at 11:46, TdEII said:

Food for thought -

 

A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2 - idemo ka malo realističnijim modeliranjem 

 

Abstract: Despite various levels of preventive measures, in 2020 many countries have suffered severely from the coronavirus 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. We show that population heterogeneity can significantly impact disease-induced immunity as the proportion infected in groups with the highest contact rates is greater than in groups with low contact rates. We estimate that if R0 = 2.5 in an age-structured community with mixing rates fitted to social activity then the disease-induced herd immunity level can be around 43%, which is substantially less than the classical herd immunity level of 60% obtained through homogeneous immunization of the population. Our estimates should be interpreted as an illustration of how population heterogeneity affects herd immunity, rather than an exact value or even a best estimate.

 

Vredi pročitati rad, dobar, jasno definisanja ograničenja i zanimljivi rezultati. Npr. 2 talas je izražen samo u slučajevima kad su uvedene vrlo restriktivne mere lockdown, koje su podignute PRE kraja (Fig. 1)

Iz rada, tabele

 

 

da li bi ti bilo tesko da u par recenica objasnis - preneses ono sto si procitao? nisam sigurna da razumem implikacije ovoga na celo drustvo (mislim, to da je imunitet krda razlicit s obzirom na starosnu grupu i aktivnost)
ako nemas vremena ili nas, opravdano, upucujes da sami citamo, na kraju cu i procitati :(

[TdEII]

@Aleksija pokušaću, za "par" rečenica daj mi malo vremena. Danas do kraja dana?

 

 U jednoj jedinoj, može odmah: "Društva su previše kompleksna da bi se posmatrala homogeno i unifromno i tzv. klasičan imunitet krda koji zahteva da min. 60% cele populacije bude imun, da bi grupa kao celina bila na sigurnom, je besmislen."

[Aleksija]

11 minutes ago, TdEII said:

@Aleksija pokušaću, za "par" rečenica daj mi malo vremena. Danas do kraja dana?

 

 U jednoj jedinoj, može odmah: "Društva su previše kompleksna da bi se posmatrala homogeno i unifromno i tzv. klasičan imunitet krda koji zahteva da min. 60% cele populacije bude imun, da bi grupa kao celina bila na sigurnom, je besmislen."

hvala ti puno

 

Edited July 3, 2020 by Aleksija

[precog]

13 minutes ago, TdEII said:

@Aleksija pokušaću, za "par" rečenica daj mi malo vremena. Danas do kraja dana?

 

 U jednoj jedinoj, može odmah: "Društva su previše kompleksna da bi se posmatrala homogeno i unifromno i tzv. klasičan imunitet krda koji zahteva da min. 60% cele populacije bude imun, da bi grupa kao celina bila na sigurnom, je besmislen."

besmislen zato sto treba fokusirati mere na najaktivnije delove drustva (mladju i aktivnu populaciju koja je najvise u riziku od zarazavanja), a ne sve tretirati na isti nacin? ima smisla, ali problem sa ovim matematickim modelom je sto mi se cini da uzima u obzir da svako ko je bio izlozen virusu nuzno ima imunitet, sto izgleda nije tacno. Nisam citao celo istrazivanje, samo ovo sto si postovao, tako da ako je to vec opisano kao ogranicenje, izvinjavam se.

[Baldrick S.]

Ja tek danas video da je ona labaratorija u Nemackoj, koju je trump hteo da kupi (bio-nesto) vec testirala prvu grupu ljudi I da treba da objavi rezultate "krajem juna, pocetkom jula".

Sent from my VOG-L29 using Tapatalk

[vememah]

 

[Tsai]

Mutirao? 

[halloween]

https://www.endocrineweb.com/covid-19-post-infection-thyroid-disease

[steins]

2 hours ago, halloween said:

https://www.endocrineweb.com/covid-19-post-infection-thyroid-disease

ovo je valjda najgluplji rad koji sam pročitao na temu COVIDa  

 

Quote

It seems the link between COVID-19 and the thyroid disease is clear. The study’s author, Francesco Latrofa MD of the University Hospital of Pisa in Italy wrote, “Because of the chronological association, SARS-CoV-2 may be considered accountable for the onset of subacute thyroiditis.”

 

Jbte, koliki šum prave sa ovim bemislenim radovima koji niču ko pečurke posle kiše 

Edited July 3, 2020 by steins

[Aleksija]

4 hours ago, vememah said:

 

e bas super 

[Boza_zvani_Pub]

11 hours ago, Aleksija said:

e bas super 

Highlights:
-A SARS-CoV-2 variant with Spike G614 has replaced D614 as the dominant pandemic form
-The consistent increase of G614 at regional levels may indicate a fitness advantage
-G614 is associated with lower RT PCR Ct’s, suggestive of higher viral loads in patients
-The G614 variant grows to higher titers as pseudotyped virions

 

Znaci, ovaj siljak na virusu je muitirao i prilagodio se malo. Nova mutacija se brze prenosi i ima je vise u pacijentima (viralnija)? Sta znaci ova poslednja recenica?

Edited July 4, 2020 by Boza_zvani_Pub