Vakcinacija

[Friend]

To mi kazi, sutra idem na pf revacc.. Prva doza nista.

 

 

 

Edited July 22, 2021 by Friend

[Friend]

Ozbiljno se premisljam da pomerim 2. dozu za mesec dana jer danas je izaslo da:

 

"Stručnjaci kažu da rezultati studije podržavaju odluku Velike Britanije da produži interval između injekcija prve i druge vakcine na 12 nedelja sa prvobitno postavljene tri nedelje.

Izgleda da je osam nedelja najbolji vremenski interval između prve i druge doze vakcine u borbi protiv delta varijante, dodaju, prenosi BBC.

Studiju je finansirala država, a objavljena je samo u štampanom izdanju i još uvek nije pregledana.

Za ovu studiju, istraživači su upoređivali imunološki odgovor 503 zaposlena u NHS koji su primali dve doze vakcine u različitim vremenskim periodima od kraja 2020. do početka 2021. godine u vreme kada se alfa varijanta ili britanski soj brzo širio.

Nivo antitela u krvi izmeren je mesec dana nakon prijema druge doze vakcine.

Evo nekoliko zaključaka iz te studije:
* i kratki i dugi intervali doziranja vakcine Fajzera stvorili su snažne imunološke odgovore u celini,
* razmak od tri nedelje proizveo je manje neutrališućih antitela koja se lepe za virus i sprečavaju ga da zarazi ćelije u poređenju sa razmakom od deset nedelja,
* nivoi antitela padaju nakon prve doze, ali nivo T ćelija - druge vrste imunih ćelija - ostaje visok,
* duži interval između dve vakcine doveo je do manjeg broja T ćelija u celini, ali do većeg udela određenog tipa ili podgrupe, zvane pomoćne T ćelije, za koje istraživači kažu da jačaju imunološku memoriju".

[Indy]

Treba oko pola sata (prva polovina je najbitnija), ali je vrlo zanimljivo (posebno za nas pelcovane Astra Zenekom.)

 

 

[Indy]

Treba oko pola sata (prva polovina je najbitnija), ali je vrlo zanimljivo (posebno za nas pelcovane Astra Zenekom.)

 

 

[vememah]

 

[omiljeni]

After refusing to receive a vaccine for COVID-19, Rick Dennison is out as a Minnesota Vikings assistant coach, sources told ESPN on Friday.

 

[Caligula]

https://m.facebook.com/story.php?story_fbid=1678352502359767&id=100005551006844

[vememah]

Vrlo važan niz.

 

Quote

Michael Lin, PhD-MD
6h ago, 12 tweets, 4 min read

 

The drop to 44% protection vs sympt dz 5mo after RNA dose2 suggests a rapid drop of circulating antibodies. The immune system does not sustain the high amounts of nAbs needed to block symptomatic infection. Makes sense it would only produce those high levels after the RNA punch.

 

 

This paper found the half-decay time of anti-SARSCoV2 antibody levels to be 2-3 months after infection.

 

 

 

Another larger study in Science similarly measured half-life of 100 days for antibodies (note log scale)

 

 

https://science.sciencemag.org/content/371/6529/eabf4063

 

There isn't a linear correlation between nAb levels and % symptomatic breakthrough of course. So here we lose 50% of the protection (~88 to 44% breakthrough rate) in 5 months, which corresponds to ~75% reduction in antibody levels. 

This is just about your ability to have high enough circulating nAb levels for mucosal immunity: stopping enough virus from entering cells that you don't even have symptoms. So even if your nAb levels have decayed and you get symptoms, the vaccines already gave you a head start 

...in that your trained B and T cells are already there and can ramp up activity upon breakthrough to produce more nAbs again and kill infected cells, preventing progression to severe disease. 

It also goes without saying that this doesn't mean your long term ability to recognize and fight SARSCoV2 is being lost with 50% probability in 5 months either. You have memory B and T cells that survive for years and can proliferate in response to re-encounters. 

So when you hear talk about immunity waning and then the next day talk about how you have lifelong protection, they are not contradictory. Your immune system is designed to react to ongoing challenges with antibody production. 

Your circulating levels of Abs wane because you can't possibly keep nAb levels high for every antigen you've ever encountered. But you still have lifelong protection in B and T cells watchfully waiting. 

This does mean that to protect against symptomatic disease which is also transmissible disease, we would need boosters every 6 months. If nearly everyone worldwide were immunized synchronously then we could reach herd immunity, i.e. the virus stops propagating. 

However it seems unlikely we can immunize everyone synchronously. So then if there are always some people with low antibody levels (whose last vaccination or last infection was >6 months ago) the virus can continue to propagate through the population as a mild cold. 

Let's rewind the tape: '“Our data from the CDC today suggests that vaccinated people don’t carry the virus, don’t get sick and that it’s not just in clinical trials, but it’s also in real world data,” said Walensky.'

Should have consulted a biologist.

 

Quote

Data Suggests Vaccinated Individuals Don't Carry Virus or Get Sick: CDC

https://www.nbcbayarea.com/news/coronavirus/vaccinated-individuals-dont-carry-virus-or-get-sick-cdc/2506677/

https://threadreaderapp.com/thread/1418743399272747008.html

Edited July 24, 2021 by vememah

[Friend]

Upravo ono sto smo spominjali da ce se korona svesti na sezonsku infekciju nesto slicno gripu - mozes da se zarazis, smlacen si par dana i to je sve.

 

- Vakcina sluzi da nas prajmuje i time zastiti od srednjeg i tezeg oblika bolesti

- Antitela debelo uticu na to da li ce biti simptoma ili ne, kako ona vremenom nestaju tako se povecava sansa za simptomatsku infekciju

- Dubinski imunitet opstaje godinama i to je jako vazno i dobro

- Svaki kontakt sa virusom obnavlja otpornost prema virusu

- Na kraju ce biti ravnoteza i prirodni balans

[Milosh76]

Pre 2 meseca imao sam antitela 55 granica 1, danas 46.8...

Fajzer druga doza pre 4 meseca.

[Nikodije]

drkon najavljuje potrebu razdvajanja vakcinisanih i nevakcinisanih. izgleda da on ne veruje u delotvornost vakcine. ja, recimo, verujem, i uopste ne vidim potrebu da me bilo ko razdvaja od bilo koga jer racunam da sam zasticen i da necu umreti ako dodjem u kontakt sa virusom.

[Malkmus]

Po britanskoj studiji dve doze Pfizera su 88% efektivne protiv Delte, a dve doze AZ 66%.

https://www.reuters.com/business/healthcare-pharmaceuticals/two-doses-pfizer-astrazeneca-shots-effective-against-delta-variant-study-finds-2021-07-21/

 

[dùda]

1 hour ago, Friend said:

Upravo ono sto smo spominjali da ce se korona svesti na sezonsku infekciju nesto slicno gripu - mozes da se zarazis, smlacen si par dana i to je sve.

Jeste, ali ovo važi za vakcinisane.

Ok, važi i za mnoge druge, prvenstveno mlade i zdrave, ali ipak, mnogi antivakseri će nastradati.

Davno je bilo rečeno, ili ćeš se vakcinisati ili ćeš se razboljeti. Trećeg izgleda da nema.

[Anduril]

Gledam statistiku po Evropi:

https://www.statista.com/statistics/1202074/share-of-population-vaccinated-covid-19-by-county-worldwide/
Prva vakcinacija se krece uglavnom oko 60% sto znaci da ce maksimum sa dve doze u oktobru biti verovatno ispod 70%. Katastrofa, delta ce poharati nevaksinisane na jesen, verovatno ce bolnice biti opet na ivici a i deca sa rizikom long-covida. 
Ako se neko ne probudi i pocne sa zaista restriktivnim merama za anti-vaksere, oni su vec uspeli da uniste skoru normalizaciju.

Edited July 24, 2021 by Anduril

[defibrilator]

Iskreno ja sam iznenadjen da ce biti bar 70% vakcinisanih. Tako da meni su ovi brojevi za Evropu i dobri