Covid-19: Razvoj vakcine, imunitet i primena medikamenata

[Spooky]

Ako je fajzer posle prve doze 85-92 efikasan (2 istraživanja koja sam procitao) zaista treba davati samo po jednu dozu. Druge vakcine su ionako manje efikasne.

 

Nema logike da se na dio populacije troši još jedna doza da bi se podigla efikasnost, dok neki drugi dobijaju vakcine sa manjom efikasnosću...

[vememah]

Quote

Russia Approves CoviVac, Its Third Coronavirus Vaccine

Russia has approved its third domestically produced coronavirus vaccine, although large-scale clinical trials of the shot have yet to be completed.

Prime Minister Mikhail Mishustin said February 20 that registration of the CoviVac vaccine makes Russia “the only country today that already has three vaccines."

The first 120,000 doses of the vaccine, produced by the state-run Chumakov Center, are expected to reach Russians by March. By the end of the year, Russia aims to have some 20 million doses of CoviVac produced.

Scientists at the Chumakov Center claim their vaccine is more than 90 percent effective against COVID-19, although Phase 3 clinical trials aren't expected to start until April.

In August, Russia approved the world’s first COVID-19 vaccine, Sputnik V, prompting scientists around the world to question its safety and efficacy because it was registered before the results of Phase 3 studies were made available.

But in early February, peer-reviewed, late-stage trial results published in The Lancet medical journal showed the two-dose regimen of Sputnik V was 91.6 percent effective against symptomatic COVID-19, about the same level as the leading Western-developed vaccines.

The vaccine has now been approved for use in some 30 countries.

A second vaccine developed in Russia, called EpiVacCorona, was registered in October and is expected to go into arms in March.

Even though Russia was early to register domestically produced vaccines, so far only about 2.2 million people in the country have received at least one of two necessary injections, or about 1.5 per cent of the population.

Unlike the Sputnik V vaccine and Western shots, the new CoviVac vaccine was developed using a whole inactive virus. A similar vaccine has been developed by China.

https://www.rferl.org/a/russia-coronavirus-vaccine-covivac/31113697.html

Edited February 21, 2021 by vememah

[Milosh76]

Evropska agencija za lekove (EMA) saopštila je da je danas po ubrzanoj proceduri počela sa ispitivanjem leka za kovid-19 Regdanvimab.

Regdanvimab je monoklonalno antitelo koje proizvodi korejska kompanija Celtrion, a EMA je odlučila da počne analizu na osnovu preliminarnih rezultata kliničkih studija.

EMA će, kako se navodi u saopštenju, nastaviti da analizira podatke kako budu pristizali, dok ne prikupi dovoljno dokaza za odluku o puštanju leka u promet.

[Aleksija]

ova imena antivirusnih lekova kao da su preuzimali iz slagalice.

[vememah]

3 hours ago, Milosh76 said:

Evropska agencija za lekove (EMA) saopštila je da je danas po ubrzanoj proceduri počela sa ispitivanjem leka za kovid-19 Regdanvimab.

 

 

[Kelt]

aha, ovo se isto kači za spike protein. Pa dobro, instant verzija vakcine. 

[vememah]

Quote

 

A new analysis of B cells and more than 1,000 different monoclonal antibodies from 8 patients with COVID-19 shows that, contrary to previous hypotheses, protective B cell responses to the SARS-CoV-2 spike protein remain stable and continue to evolve over a 5-month period, many months after the initial period of active viral replication.

However, a large proportion of the neutralizing antibodies generated from these long-lasting B cells did not efficiently recognize various emerging SARS-CoV-2 variants from Brazil and South Africa.

 

https://www.news-medical.net/news/20210223/Long-lasting-B-cells-do-not-recognize-emerging-SARS-CoV-2-variants-shows-study.aspx

 

Studija:

https://immunology.sciencemag.org/content/6/56/eabg6916

[Dankan Ajdaho]

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247163

[Have_Fun]

https://www.b92.net/zdravlje/vesti.php?yyyy=2021&mm=02&dd=25&nav_id=1817605

Antitela koja nastanu kod onih koji su preležali kovid 19 nakon srednje i teške kliničke slike su na sličnom nivou onih koja se steknu nakon imunizacije.

 

[Desmond Bojčinski]

Iz iskustva zaraženih kolega, najkraće zadržana antitela su bila 2 meseca, doduše posle 2 doniranja plazme. 

E sad, količina antitela se kretala između 40 i 80 hiljada(nekih jedinica) mesec dana posle prvog negativnog testa, dok je posle 3 nedelje druge doze Fajzera vrednost išla od 400(jedan pred penziju) do 900 hiljada nečega. 2 nedelje posle Kineza vrednosti su bile 150-200 hiljada.

[Have_Fun]

Ja sam pregurao kovid krajem oktobra/pocetak novembra

Bio sam u kontaktu (kad kazem u kontaktu, ne mislim da smo se mimoisli, nego je zaista bio kontakt) sa kovid zarazenom osobom, hvala Bogu, nista mi nije bilo.
Da li i dalje imam antitela ili je puka sreca, ne znam.. nisam radio test na antitela sad u februaru.. pre FEB sam ih imao.

[Krošek]

već i samo jedna doza fajzera čini veliku korist jer dosta smanjuje širenje

https://www.cam.ac.uk/research/news/single-dose-of-pfizer-biontech-vaccine-reduces-asymptomatic-infections-and-potential-for-sars-cov-2

[omiljeni]

https://www.bbc.com/news/world-us-canada-56186965

 

US regulators have found the single-shot Johnson & Johnson coronavirus vaccine is safe and effective.

It paves the way for it to become the third Covid-19 vaccine to be authorised in the US, possibly within days.

 

[Moracikus]

Ocekuje se za koji dan objavljivanje preliminiranih rezultata iz SADa koji sadrze dovoljno ljudi starijih od 65.

Problem ostaje relativno niska efikasnost jer jednostavno nisu imali dovoljno vremena da cekaju 3 mjeseca izmedju doza za svih 30k ucesnika.

Vecina ce ih biti 4-6 nedjelja tako da ocekujem slicne rezultate kao iz UK.

[vememah]