Covid-19: Razvoj vakcine, imunitet i primena medikamenata

[vememah]

Quote

 

The Oxford vaccine is expected to be approved within days of Christmas, kickstarting a massive drive to give jabs to millions of people in January, The Telegraph can reveal.

Senior Whitehall sources believe the Medicines and Healthcare Regulatory Agency (MHRA) will authorise the vaccines on December 28 or 29 after final data is provided to the regulator on Monday.

Football stadia and other sites across the country will then be opened from the first week of January, to allow mass vaccinations on a scale never seen before in the UK. 

 

https://www.telegraph.co.uk/news/2020/12/18/exclusive-oxford-coronavirus-vaccine-expecting-approval-within/

[Baldrick S.]

Britanci se bas trude da imaju live rimejk "27 days later"

[vememah]

Quote

A nurse at a hospital in Connecticut became one of the first people in the United States to receive the Moderna Covid-19 vaccine on Monday. Mandy Delgado, who works for Hartford Healthcare, was administered the shot around 11:40 am (1640 GMT), according to a live feed of the event. "I'm excited. I feel privileged," the critical care nurse said afterwards, to a loud round of applause.

The first Moderna inoculations come after the US Food and Drug Administration (FDA) announced late Friday that it had granted emergency approval for the vaccine.

It also comes exactly a week after the US, the country hardest hit by the coronavirus, began administering the Pfizer-BioNTech vaccine.

The Moderna vaccine can be stored at -20 degrees Celsius (-4 degrees Fahrenheit), much lower than Pfizer's vaccine which must be stored at -70 degrees Celsius (-94 degrees Fahrenheit), making it easier to distribute. Since the FDA granted Pfizer-BioNTech vaccine emergency authorization one week ago, some 2.9 million doses have been delivered in the US, officials say.

https://www.france24.com/en/live-news/20201221-us-administers-first-moderna-vaccines

Edited December 21, 2020 by vememah

[vememah]

Quote

 

Life will not ‘go back to normal’ until at least half the population is vaccinated

 

Coronavirus modelling indicates that even if high-risk groups are vaccinated, death rates and hospitalisations would continue if measures were relaxed before the virus had been controlled in the general population.

21st December, 2020 at 17:23

 

Vaccination alone will not be enough to bring coronavirus in the community down to “very low levels”, and social restrictions may have to continue until around 50 per cent of the population has been vaccinated, an expert has said.

Many people have been hoping for a return to normal once the elderly and those most at risk from COVID-19 have received the jab.

But scientists say this might not be enough to see an end to measures such as social distancing and wearing face masks.

They suggest restrictions may be needed until at least half of the UK’s population has had the coronavirus vaccine.

Stephen Evans, professor of pharmacoepidemiology at the London School of Hygiene and Tropical Medicine, said vaccination alone will not be enough to bring the virus circulating in the community to “very low levels”.

“We actually need to have the absolute amount of virus circulating to be very low,” said Evans at a press briefing arranged by the Science Media Centre.

“And we won’t do that by vaccination alone until we’re getting 50 per cent of the population vaccinated or more, and that’s going to be quite a bit of a long way off yet.

“So I fear that the sort of restrictions we have, the non-medical interventions, are going to need to be carried on.”

“I think if people take these seriously, then it’s possible for various economic activities to go ahead, but you have to make sure that you are keeping to the non-medical interventions, being aware and behaving as if every person you contact has got the virus. And that you have it as well,” added Evans.

“And when you behave in a way that realises that, and that the consequences for either you or the person around you getting the virus can be very serious, then it changes people’s behaviour.

“And we’re going to have to go on doing that for quite a long time.”

Health Secretary Matt Hancock said that as of 8am on Saturday 19 December 2020, 350,000 people had been vaccinated.

Adam Finn, professor of paediatrics at the University of Bristol, said that even if the elderly are vaccinated, social restrictions may have to continue for some time.

“I think the modelling is very clear that even if you had high coverage and high levels of protection in the high-risk groups, you would still see epidemics, and large numbers of hospitalisations and deaths if you relax the measures before you have a broader control of viral circulation in the population at large,” said Finn.

“So I think the idea that you can immunise a large proportion of the elderly and then kind of go back to normal is misguided.

“I think that none of the models suggest that that’s going to be possible.”

Peter Openshaw, professor of experimental medicine at Imperial College London, said he is concerned about the hard to reach in the community – people who are very doubtful about vaccines or those not very well informed. He said this is something that needs to be focused on.

He added that the efficacy of the Oxford-AstraZeneca vaccine, which is yet to receive regulatory approval, against transmission may be “considerable” even if it is not as effective as the other options.

There have been some concerns the Oxford vaccine may not be as good as preventing symptomatic disease as the others, but the experts suggested it would be adequate for very strong population-wide effects if widely deployed.

The experts said it is not yet possible to say how much of the population needs to be vaccinated to achieve herd immunity.

They explained that while there is insufficient evidence on how effective the vaccines are at reducing transmission, the Pfizer vaccine developed with BioNTech and the Moderna jabs have demonstrated such high efficacy, it would be surprising if there was no impact on transmission.

Openshaw explained that as well as the elderly, there has to be concern about the effects of long COVID in relatively young people.

He said he found the idea of his colleagues or his relatives becoming affected by long COVID “terrifying”.

“We shouldn’t stop vaccinating once we have just vaccinated the high risk,” said Openshaw. “I think we have to get the population vaccinated and I think the prospects of vaccines preventing long COVID are quite good.”

 

How do scientists develop vaccines for new viruses?
Vaccines work by fooling our bodies into thinking that we’ve been infected by a virus. Our body mounts an immune response, and builds a memory of that virus which will enable us to fight it in the future.

Viruses and the immune system interact in complex ways, so there are many different approaches to developing an effective vaccine. The two most common types are inactivated vaccines (which use harmless viruses that have been ‘killed’, but which still activate the immune system), and attenuated vaccines (which use live viruses that have been modified so that they trigger an immune response without causing us harm).

A more recent development is recombinant vaccines, which involve genetically engineering a less harmful virus so that it includes a small part of the target virus. Our body launches an immune response to the carrier virus, but also to the target virus.

Over the past few years, this approach has been used to develop a vaccine (called rVSV-ZEBOV) against the Ebola virus. It consists of a vesicular stomatitis animal virus (which causes flu-like symptoms in humans), engineered to have an outer protein of the Zaire strain of Ebola.

Vaccines go through a huge amount of testing to check that they are safe and effective, whether there are any side effects, and what dosage levels are suitable. It usually takes years before a vaccine is commercially available.

Sometimes this is too long, and the new Ebola vaccine is being administered under ‘compassionate use’ terms: it has yet to complete all its formal testing and paperwork, but has been shown to be safe and effective. Something similar may be possible if one of the many groups around the world working on a vaccine for the new strain of coronavirus (SARS-CoV-2) is successful.

 

https://www.sciencefocus.com/news/covid-19-vaccine-uk-when-will-life-go-back-to-normal/

[vememah]

Vakcinacija u zemljama EU počinje 27.12.

 

 

[Tsai]

Aj nek nam je svima sa srecom 

[vememah]

 

[duma]

Za to vreme na jednoj od normalnijih televizija s nacionalnom frekvencijom (nije Pink i Happy) u jutarnjem programu ide:

Srpski kardiolog o vakcinama: "Sačekajte. Ne mogu da preporučim genetski modifikovanu" 

Posle to prenosi i sajt B92. 

U tekstu imamo:

Quote

Kako je objasnio, smrtnost od korone je 0,14 odsto, a od srčanog udara 65 odsto.

"Smrtnost od malignih bolesti je 30 odsto, sve druge bolesti su dakle 90 odsto", poručio je on gostujući u "Jutru" na TV Prva.

...

Kaže i da bi mogao da preporuči svojim pacijentima vakcinu, mora prvo da bude upoznat sa njom i njenim sastavom, a kako kaže, malo se o tome zna.

...

"Ona ima svoje promotere... Kada je pre 10 godina bio svinjski grip, SZO je mesec dana pre toga objavila da će biti epidemija i smanjila kvotu za proglašavanje epidemije i šta se desilo, niko se nije ni zakašljao. Nemačka je platila 80 miliona evra za vakcine, Srbija dva miliona evra... Moj je savet - sačekajte", zaključio je dr Hadži-Tanović.

Izgleda će naši stručnjaci smrtnost s preko 2 posto da svuku na 0,14 (statistika naša dika).

Ne znam, ali imam mišljenje.

Dok ne dobijemo vakcinu 2025.

 

[Dankan Ajdaho]

Ali čovek najstrašnije lupeta...uopšte se nije udubio u probelmatiku, očigledno je da nije pročitao ni jedan ozbiljan rad u vezi Fajzerove i Modena vakcine. Jebeno neverovatno. Ali zato uspeva da povrati poneki savet.

 

[harper]

1 hour ago, duma said:

Za to vreme na jednoj od normalnijih televizija s nacionalnom frekvencijom (nije Pink i Happy) u jutarnjem programu ide:

Srpski kardiolog o vakcinama: "Sačekajte. Ne mogu da preporučim genetski modifikovanu" 

Posle to prenosi i sajt B92. 

U tekstu imamo:

Izgleda će naši stručnjaci smrtnost s preko 2 posto da svuku na 0,14 (statistika naša dika).

Ne znam, ali imam mišljenje.

Dok ne dobijemo vakcinu 2025.

 

 

Trebalo bi neko ovom Hadzi-Tanovicu da skrene paznju da se od korone mnogo ljudi itekako zakasljalo i da analogije sa svinjskim gripom ili bilo kojom drugom bolescu posle godinu dana pandemije jednostavno vise uopste nisu bitne, jer posle godinu dana svaka zarazna bolest postaje kategorija za sebe. Kakve veze ima jebeni svinjski grip, obicni grip, prehlada, hemoroidi, hipertenzija, kuga ili bilo koja druga bolest s koronom? I gde mediji nalaze ovakve budale da mi je samo znati?

[vememah]

...

Edited December 22, 2020 by vememah

[omiljeni]

14 minutes ago, harper said:

 

Trebalo bi neko ovom Hadzi-Tanovicu da skrene paznju da se od korone mnogo ljudi itekako zakasljalo i da analogije sa svinjskim gripom ili bilo kojom drugom bolescu posle godinu dana pandemije jednostavno vise uopste nisu bitne, jer posle godinu dana svaka zarazna bolest postaje kategorija za sebe. Kakve veze ima jebeni svinjski grip, obicni grip, prehlada, hemoroidi, hipertenzija, kuga ili bilo koja druga bolest s koronom? I gde mediji nalaze ovakve budale da mi je samo znati?

bukvalno juče samo video vest da je od korone umro lekar u Beogradu, mislim baš da je pisalo da je sa kardiologije i to načelnik neke klinike i profa na faksu.

a onda mu kolega kardiolog Hadži-Tanović danas valjda posthumno objašnjava da je umro uprkos odličnim šansama od 99.86% da pretekne.

jebiga, bad beat, zalomilo se, danas svako zna da igra fudbal da ubije šezdesetogodišnjaka, korona je okrugla

kakvi su to ljudi jebote

 

 

[dùda]

Gde mi živimo jbt.

Ovakvi likovi bi trebalo da snose posledice za svoje nastupe. Najmanje finansijske. A još bolje da budu primorani da se javno posipaju pepelom.

Idiot 

[vememah]

Quote

Robert Peston, 1h, 6 tweets, 1 min read

1) The data shows that the vaccine reduces serious illness and risk of mortality from around 10 days of having just first dose.

2) The risk of acute illness, hospitalisation and mortality is highest in the tenth of population who are over 80 or clinically most vulnerable. 
3) Tier 4 lockdown is designed primarily to protect the NHS from being overwhelmed by those whose Covid19 symptoms require hospital treatment.

4) Tier 4 lockdown is coming to a region near you very soon, if you are not there already.

5) Tier 4 is economically devastating.
6) The costs of a military style operation to vaccinate us would be huge, but they would be a fraction of the economic costs of Tier 4 lockdown.

7) The top priority, by a country mile, of any rational government would therefore be to create the infrastructure for millions of vaccinations per week (I am assuming that the Oxford/AZN vaccine, which is easiest to distribute and of which the government has bought enough for 50m people, is approved in coming days).

8) The threat from the more infectious new Covid-19 strain only strengthens the case for accelerating the vaccination programme to the maximum safe speed.

9) I haven't bothered to make the case that speedier vaccination will save many thousands of lives, possibly tens of thousands, because it's too obvious to mention.

10) I am simply saying there is no economic or financial argument against spending whatever it takes to get the vaccine into us as quickly as possible. 

https://threadreaderapp.com/thread/1341355872761593857.html

Edited December 22, 2020 by vememah

[Filozof manijak]

Umiru zdravi ljudi od 40ak godina, mamicu imjbm bezobraznu, od čega je ovoliko povećana smrtnost u Srbiji? Od novih mercedovih autobusa proizvedenih u Rakovici. Ovim nadrilekarima koji lažu narod treba prvo oduzeti l8cencu a onda ih obesiti za palčeve na savskom trgu kao novogodišnju dekoraciju za žir. 

Mmu imjbm svima!