Eraserhead Posted October 8, 2015 Posted October 8, 2015 Ća sam reka loše? :zbunj: Ma zezam se. Cinilo mi se kao da je moje amerikanstvo manje vazno. :D
dragance Posted October 8, 2015 Posted October 8, 2015 Pa ja svaka dva meseca provedem barem dve nedelje po USA, uzduz i popreko, pa se ipak ne svrstajem kao neko ko "zna bolje" kakav je mentalitet stanovnistva od nekoga ko je tu godinama. Mada, mi Srbi smo sampioni u poznavanju svih materija/predmeta.
condor Posted October 8, 2015 Posted October 8, 2015 Ти си бре к'о из оног прастарог вица - јес ти ћито На Дрини ћуприју? Ћуј ба ћито, одо по њој!
djili Posted October 8, 2015 Posted October 8, 2015 Ти си бре к'о из оног прастарог вица - јес ти ћито На Дрини ћуприју? Ћуј ба ћито, одо по њој! kaže se hodo
dragance Posted October 8, 2015 Posted October 8, 2015 Dobro. Ne dozvolite da vas zadrzavam. Nastavite kako ste dobro upuceni kakav je mentalitet u NC ili IA.
iDemo Posted October 8, 2015 Posted October 8, 2015 Dobro. Ne dozvolite da vas zadrzavam. Nastavite kako ste dobro upuceni kakav je mentalitet u NC ili IA. +11
Eraserhead Posted October 8, 2015 Posted October 8, 2015 Malo se slegla prasina pa sada imamo i zacetke debate: In defense of Martin Shkreli Meghana Keshavan Meghana covers early stage innovation in the life sciences for MedCity News. Previously, she's worked for Reuters, Crain’s Detroit Business, the San Diego Business Journal, the Detroit Metro Times, the Detroit Free Press and WDET, a Detroit-based National Public Radio affiliate. Meghana studied biochemistry and molecular biology at Penn State University and spent five years as a self-described "research peon in a schizophrenia genetics lab." You can settle with the self-appointed superiority of the Twitter mob: Martin Shkreli is an unrepentant, deluded psychopath. Or, you can swallow hard and admit that a few things that Martin Shkreli said are likely right: That prices for many drugs, particularly antibiotics and rarely used generics, are too low. That PhRMA and BIO are sycophantic. That Shkreli may not be such a rogue CEO at all – and that behind closed doors, many more are cut from the same cloth. That funding future research with steep upfront prices could, if wielded correctly, help even out new drug prices once they’ve hit the market. Last Friday, Shkreli spoke on MedCity News’ weekly show MedHeads – and defended his pricing of Daraprim at Turing Pharmaceuticals. You can see the discussion here. Shkreli said he’s fielded thousands of phone calls and has spoken to countless journalists, but his message has been lambasted across the board. He’s biopharma’s bad boy. However, here’s the silver lining: People are talking about drug prices. Before it’s inevitably buried in the news cycle, we must grasp onto the lessons we can actually learn from Shkreli. Because in some measure he’s right. Shkreli’s argument on MedCity News is that Daraprim is a fairly ineffectual drug that’s only prescribed to some 2,000 patients – and costs a mere $13.50 per pill. Bringing that price up to $750 a pop, Shkreli argued, would bring Turing “to the break-even point.” Whether or not there’s legitimacy to that statement is up for hot debate – with most experts and the media convinced he’s just peddling more psychopathy. However: $13.50 per pill really is quite low, from a company standpoint and an ROI standpoint. There are countless drugs that sit on pharmaceutical company shelves – either paused in the development process or simply too unprofitable to produce. Hiking up the price for an ill-used drug does have its merits, if it does ideally help generate research for a better next-generation product. Whether Shkreli will actually follow through on his claims is dubious, given his track record at Retrophin. But there’s a case to be made for making uncommonly used drugs, even if they’re off-patent, more expensive – and let the insurance companies deal with the bottom line. Then there’s the example of antibiotics – which in particular are mass-produced and prescribed with abandon. That’s led to increasing rates of bacterial resistance. Reducing the accessibility of over-prescribed drugs like amoxicillin may actually help lessen the spread rate of hardy bugs that cause terrible illnesses. Increasing the costs of these antibiotics might actually help curb overprescription rates, particularly in underdeveloped countries that lack the infrastructure to regulate dosage and administration rates. PhRMA and BIO ejected Shkreli from their respective trade groups. But they have actually been criticized, in their own right, for barring transparency in issues like drug pricing. As they are advocates more for the biopharmaceutical industry than for, say, patients or providers, the immediate stance for such a trade group tends to be to protect one’s own. It’s one thing to ban Turing Pharmaceuticals from their ranks, but yet another to really crack down and analyze similar practices going on in many other firms. We’re an industry fraught with constant boosting of prices, ostensibly to fuel R&D – but the numbers are hard to reconcile. Take the drug colchicine, a 3,000-year-old medicine used to treat gout that’s been broadly reported on just this past week. Until Shkreli boldly defended his stance on hiking up his drug’s prices, the controversy around colchicine had been forgotten by the broader public – despite ongoing conversation about how the drug costs are just too damn high. Pharma CEOs make decisions like Shkreli all the time, albeit in a less brash manner. Price hikes slip under the radar frequently. Take the rising cost of commonly prescribed diabetes drugs: Costs rose 150 percent for six popular, brand-name diabetes drugs in the past five years. Two of these drugs rose in price more than 250 percent. In 2012, the cost of treating diabetes was $245 billion The spend on insulin and other diabetes medications is projected to rise 18.3 percent over the next three years – a rate that’s 60 times greater than the income growth rate of 0.3 percent across all households. Many of the drugs used to treat diabetes are off-patent. The disease’s incidence is rising at an uncontrolled rate. And yet, the prices are increasing. Why? Shouldn’t the greater drug production help curb costs? You’d imagine so – and yet we’re paying more and more for the same drugs. Something’s got to give. There’s a lot more to criticize in hiking the price of ubiquitous drugs than those that are used seldom. Shkreli is the scapegoat here – the face of a confusing and money-hungry pharmaceutical industry. In any case, here’s another thought: Is Martin Shkreli the kind of CEO life science needs? A brash, tech-heavy dude-bro that breaks the rules. He’s more Uber than AbbVie. The current biopharma industry is stuffed with buttoned-up white men in grey suits, brokering deals behind closed doors and then speaking in code during investor calls and, of course, JP Morgan. It’s truly incredible: One biopharma CEO that just happened to be unapologetic and asinine managed to move markets – and potentially pop the biotech bubble. This is largely because of his public persona and the internet’s mob-like mentality to crucify anyone that’s perceived, well, as a douche. But others that have behaved accordingly didn’t move the bar, and didn’t get the broader public talking. Maybe we need a few more Shkrelis in our midst – if only to shake things up and get people thinking.
3opge Posted October 8, 2015 Posted October 8, 2015 Malo se slegla prasina pa sada imamo i zacetke debate: neki dan na radiju zakljucise da ce ovaj bedni kopilan verovatno biti ustreljen.
ObiW Posted October 8, 2015 Posted October 8, 2015 (edited) For the record: gun control полемика која се (не) води у Америци је првенствено о маркетингу и продаји оружија, а тек тамо негде у неким будућим фазама о разоружавању становништва. Прво треба зауставити прилив. И по томе је Америка веома специфична јер нигде другде на свету, у иоле уређеним државама (да, укључујући и Косово) није до те мере лако пазарити аутоматско наоружање Ovo je kao da kazes e ajde da mi prvo projektujemo i napravimo karoseriju od auta i stavimo mu tockove, a posle cemo vec nekako da ubudzimo unutra neki motor. Jbg, trebaju nam cetvorotockasi, frka je, ko ima vremena da strateski razmislja o celom autu? А ово за грађански рат ти је јако безвезе. Американцу можеш и бубрег да извадиш, само ако му прво натенане објасниш да то мора тако, и ако види да и свим његовим комшијама такође ваде бубрег. А и не односи се само на Амере. E care, i meni bi, da zivim preko okeana, americki gradjanski rat (koji se, btw, dogodio jednom u proslosti), bio mnogo haha al je smesno, sta ovaj tenkre lupa, ihihi, pa svi znamo da su Ameri mentoli progutali bi oni svasta samo kad im se servira u lepom pakovanju. Da pak zivim u Kanadi, vec bih bio mnogo suzdrzaniji u prognozama sta je stvarno a sta moguce kod juznih suseda, iz prostog razloga sto pogresna procena moze zauvek da upropasti moj socijaldemokratski nacin zivota kojim se ponosim. Edited October 8, 2015 by ObiW
condor Posted October 9, 2015 Posted October 9, 2015 Ударили смо у тешку генералију, једва да може горе. For the record: Амери су народ к`о и сваки други, ни бољи ни гори. Т.ј. разни би се други народи на њиховом месту понашали баш као Американци. Нпр. начин на који су Срби купили Језду и Дафину и метод којим су се Амери уфурали у the housing bubble - то ти је иста ствар. Начин на који је међу Американцима створена зверска мржња према Јапанцима, па након рата брже-боље урађен такође веома ефикасан undo, неподношљива лакоћа са којом им је могуће продати врло провидне глупости о нпр. Русима... Велика депресија, New Deal, WWII, амерички сан, Вијетнам, dot.com, дуга је историја америчких масовних заблуда и буђења. И све је код њих за нијансу драматичније и веће, гласније но код других. Грађански, дакле, рат? Може, куме, још како. К`о и код нас: ако тако буду одлучили они који могу да одлучују о томе. Circular definition, eh? :) Ја само покушавам да кажем да су народи - сви народи - подложни манипулацијама. А могуће је да је и величина манипулације пропорционална величини/ моћи народа. Тако да разоружавање неће бити неки специјалан проблем, ако powers to be одлуче да им је у интересу. Ако.
Eraserhead Posted October 9, 2015 Posted October 9, 2015 Нпр. начин на који су Срби купили Језду и Дафину и метод којим су се Амери уфурали у the housing bubble - то ти је иста ствар. Nidje veze.
iDemo Posted October 9, 2015 Posted October 9, 2015 Dobro. Ne dozvolite da vas zadrzavam. Nastavite kako ste dobro upuceni kakav je mentalitet u NC ili IA. IA?? Bil Brajson IA?
Recommended Posts