iDemo Posted August 24, 2021 Share Posted August 24, 2021 Quote Transmission of SARS-CoV-2 Delta Variant Among Vaccinated Healthcare Workers, Vietnam 31 Pages Posted: 10 Aug 2021 https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3897733 Quote Link to comment
Kelt Posted August 24, 2021 Share Posted August 24, 2021 On 22.8.2021. at 1:28, vememah said: Quote Link to comment
Amos Posted August 24, 2021 Share Posted August 24, 2021 @Kelt, daj savet za treću vakcinu kad si već tu Fajzer ponovo ili da šaram? Šta ćeš ti odabrati? Quote Link to comment
ZeeGerman Posted August 25, 2021 Share Posted August 25, 2021 https://clinicaltrials.gov/ct2/show/NCT04889040 I mi smo na listi Show 204 study locations: Serbia Health Centre 'Dr. Dragisa Misovic' Cacak Not yet recruiting Cacak, Serbia, 32000 Poliklinika Kragujmedic Withdrawn Kragujevac, Serbia, 3400 Clinical Center Nis Not yet recruiting NIS, Serbia, 18000 Clinical Centre of Vojvodina Not yet recruiting Nova Sad, Serbia, 21000 Health Center Uzice Not yet recruiting Užice, Serbia, 500821 Health Center Valjevo Not yet recruiting Valjevo, Serbia, 14000 1 1 Quote Link to comment
Aleksija Posted August 25, 2021 Share Posted August 25, 2021 sta li je RO7496998? Quote Link to comment
Skyhighatrist Posted August 25, 2021 Share Posted August 25, 2021 34 minutes ago, Aleksija said: sta li je RO7496998? RO7496998 (AT-527) Atea Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company engaged in the discovery and development of oral therapeutics for severe viral infections, today announced positive interim results from the global Phase 2 study evaluating AT-527 in hospitalized patients with mild-to-moderate COVID-19. Roche and Atea are jointly developing AT-527, an oral direct-acting antiviral (DAA) agent derived from Atea’s purine nucleotide prodrug platform. 1 1 Quote Link to comment
iDemo Posted August 25, 2021 Share Posted August 25, 2021 Quote Questions for FDA Komentari ispod klipa su zreli za fektček™... a) tačno: "Scott Gottlieb (23rd Commissioner of) FDA resigns and becomes a member of Pfizer's board of Directors", b) nije tačno: "Stephen Hahn (24th Commissioner of FDA) replaces Gottlieb and then resigns to become Moderna's chief medical officer". Stephen je presao u Flagship Pioneering, The Investor behind Moderna... Dakle, to je tačnije™... Sto bi neki rekli "Nice happy little family that the FDA and pharma have"... #quote J. Paul FDA: Food and Drug Administration (US) Quote Link to comment
iDemo Posted August 26, 2021 Share Posted August 26, 2021 @Aleksija, pomoc?! Je l' se zna sta tacno znaci 'dose spacing' u "...with the 8-12 week dose spacing compared with 3-6 weeks" ako na '3-6 week interval' (na X-osi) nema podataka za "Post-1st dose"? Pogledao sam i na tviteru i direktno u ResearchSquare-u. Ili bolje da se oslonim da disclaimer: Quote This preprint is under consideration at a Nature Portfolio Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Quote Link to comment
Gojko & Stojko Posted August 26, 2021 Share Posted August 26, 2021 26 minutes ago, iDemo said: @Aleksija, pomoc?! Je l' se zna sta tacno znaci 'dose spacing' u "...with the 8-12 week dose spacing compared with 3-6 weeks" ako na '3-6 week interval' (na X-osi) nema podataka za "Post-1st dose"? Pogledao sam i na tviteru i direktno u ResearchSquare-u. Ili bolje da se oslonim da disclaimer: Evo da probam ja druže Radovane - kao što je hors rejsing rejs bitvin horses, tako je i doz spejsing spejs bitvin dozis, capiche? Na X osi nema tačka (ne bih znao šta ti ovo znači da nema "podataka") zvana "Post-1st dose", ali nije reč o tome, reč je o poređenju nivoa antitela nakon druge doze u setu uzoraka gde se druga doza dala nakon dužeg intervala nego u prvom setu uzoraka. Ili što bi rekao Pol Dempsi iz benda "Soemthing for Kate", a u pesmi "Monstrumi": Coz I don't want to be a container Or a bastard with a ten page disclaimer SaE 1 1 Quote Link to comment
iDemo Posted August 26, 2021 Share Posted August 26, 2021 10 minutes ago, Gojko & Stojko said: SaE Hvala, brt. Ko pita ne skita... Inace, kompletna "Figure 1" (sa linka gore) ... Quote Link to comment
Gojko & Stojko Posted August 26, 2021 Share Posted August 26, 2021 24 minutes ago, iDemo said: Hvala, brt. Ko pita ne skita... Inace, kompletna "Figure 1" (sa linka gore) ... Molim, i drugi put. Evo i sažetka sa kraja, sve fino izloženo (ako sam dobro pratio, Kanađani su jurili da što više ljudi vakcinišu prvom dozom, pa je usled nedovoljne brzine pristizanja vakcina iz Am'rike došlo do kašnjenja u davanju druge doze u odnosu na od Fajzera preporučeni interval, pa je slučajno ispalo da je nivo antitela viši. Kod nas urgiraju da ljudi prime drugu dozu AZ što pre, vođeni logikom da je imunitet svakako viši nakon dve doze nego nakon samo jedne, a ionako imaju AZ za bacanje): Delayed dosing of mRNA COVID-19 vaccines has been a politically controversial issue, based primarily on pragmatic reasoning aimed at mitigation of vaccine shortages, rather than scientific justification. The main findings of this comparative assessment of humoral and cellular immune response in HCWs receiving 2 doses of the BNT162b2 vaccine were as follows: 1) all health care workers, regardless of regular or delayed dosing intervals, produced robust immune responses after two doses of the vaccine, 2) interestingly anti-RBD antibody titres were significantly enhanced by a delayed interval while neutralizing antibody responses were robust in both groups, 3) cellular immune response represented by spike-specific monofunctional and polyfunctional CD4+ T-cells were detectable in both groups but may be slightly lower in the delayed vaccination group. Less impact of delayed dosing was apparent upon the CD8+ T-cell response. The data presented herein provide scientific rationale to support delayed dosing policies for mRNA vaccines especially since currently there are limited peer-reviewed published data reporting on this. Concern has been raised that delaying the interval of the 2 doses of vaccine may encourage the development of new SARS-CoV-2 variants in the interim while awaiting the second dose3. This may be off-set, however, by the higher anti-RBD titres achieved in the delayed vaccination group, possibly conferring a more durable response and longer-term protection, as well as potentially increasing the likelihood of sufficient antibody level to confer efficacy against heterologous and partially vaccine resistant variants. The greater humoral response achieved by delaying mRNA vaccination is consistent with studies of delaying the second dose of vector-based (ChAdOx-1) vaccine 5. SaE 1 Quote Link to comment
Friend Posted August 26, 2021 Share Posted August 26, 2021 (edited) Da li bi se mogla izvuci linearnost tj. da li je 6w bolje od 3w ili postoji nekakav threshold na 8w? Jer imam neke bliske koji su primili na 6w razmaku. Edited August 26, 2021 by Friend Quote Link to comment
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.