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Covid-19: Razvoj vakcine, imunitet i primena medikamenata

bey
bey
in Covid-19 Coronavirus

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Taj CureVac je cisto nemacka mRnk vakcina, za koju tvrde da rnk nije sinteticki vec uzet iz prirode.

Navodno maksimalno koliko prirodno moze da bude.

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Allie Nawrat: How does CureVac’s CVnCoV differ from the other mRNA vaccines in development, such as Moderna’s and Pfizer/BioNTech’s?

 

[CureVac chief technology officer] Mariola Fotin-Mleczek: We spent many years researching naturally occurring mRNA molecules and now have a library of elements that can be used to build the specific mRNA nucleotide sequence needed for each specific protein. We are now leveraging this extensive expertise into the safe and rapid development and manufacturing of our Covid-19 candidate.

CureVac’s approach is to use non-modified mRNA. We believe this enables improved interactions with intracellular translation machinery, leading to high protein production and a moderate activation of innate immunity. We [also] believe this approach closely mimics the natural immune response to Covid-19; our studies confirm that we see similar ratios of binding and neutralising antibodies in vaccinated individuals and convalescent patients.

The dose of CVnCoV proposed for Phase IIb/III [trial] is the lowest dose of any of the mRNA vaccine candidates in advanced clinical trials. Our optimisation process enables high expression levels of the encoded protein, which ultimately means we can use a lower dose.

 

AN: How has CureVac developed an mRNA vaccine that does not require ultra-cold refrigeration?

 

MF-M: The most obvious difference between our vaccine and the other mRNA-based vaccines is the use of natural, non-modified mRNA, which impacts secondary structure and packing of mRNA, which can make mRNA less affected to hydrolysis. This is one of the possible explanations. But, also, the matrix can differ between different mRNA approaches.

 

https://www.pharmaceutical-technology.com/features/mrna-vaccines-covid19-pandemic-curevac/

 

 

Edited by vememah

Nešto razmišljam, Ugur Sahin je pre svega onkolog. Može da se dogodi da teraju lisicu a isteraju vuka, pa na kraju ovih istraživanja i razvoja vakcina dođu do vakcine protiv kancera širokog spektra.

Edited by halloween

    • +1 5

    Malo o kubanskim vakcinama.

     

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    Two Cuban COVID-19 vaccines are in solid progress to be available in summer, Dr. Rolando Perez Rodriguez, director of Science and Innovation at the Cuban Biotechnology and Pharmaceutical Industries Group (BioCubaFarma), told Anadolu Agency in an exclusive interview...
    Two vaccine candidates – Soberana 02 and Abdala – are now in Phase III clinical trials, Rodriguez said, with ''efficacy data expected by June."
    "However, positive safety and immunogenicity data from these vaccine candidates have been obtained in previous clinical trials," he added.
    He said Cuba plans to complete vaccination of all its people, against all odds, before the end of this year and drew attention to "a shortage worldwide for available supplies of raw materials and primary packaging material for the pharmaceutical industry."

     
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    With around 100,000 Cubans having received the jab so far, the island is behind the average Latin American vaccine rollout of 12% of people having received at least one dose. And with no vaccine yet fully approved for use by the island’s regulator, critics say the Communist party’s decision not to join Covax, the UN-backed mechanism to distribute Covid-19 doses fairly around the world, was arrogant and has left them needlessly exposed.

     
    FINLAY-FR-2 tj. Soberana 2 je konjugovana vakcina, a CIGB-66 tj. Abdala je proteinska.

    Edited by vememah

     

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    Edited by vememah

    • +1 1

     

     

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    11 minutes ago, Aleksija said:

     

    jedva cekam da iskombinujem kineza sa nekom mrna, pristajem i dzabe.

    I ja

    Ali kakve smo sreće, ponudiće nam trećeg kineza :dry:

     

    • +1 2

    Meni ta tehnologija deluje najbezbednije, ali dok ne krene u masovnu primenu ne može da se zna. A koliko sam video teško da će je biti ove godine.

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