Covid-19: Razvoj vakcine, imunitet i primena medikamenata

[Moracikus]

Po twitteru vidim da se NVAX ucesnici uglavnom hvale da nemaju neke jace bolove, glavobolje .... Manje nego za ostale na primjer.

U pitanju je kompanija koja je imala vrtoglavi rast cijena akcija u prosloj godini i obecavaju da mogu do kraja 2021 da izrolaju 3BN doza.

Dosta su i skupi u odnosu na ne-mRNA vakcine.

Rezultati iz Juzne Afrike i UK stizu za desetak dana. JNJ objavljuje 21. Jan. Tako da ce to biti u isto vrijeme.

 

Ako bude <90% bice razocarenje za one koji su vec kupili akcije jer vidim da ocekuju 95+

 

JNJ ce vjerovatno biti clago razocarenje tu nedje oko AZN vrojeva. Tako je to kad radis za 0% profita.

 

[borris_]

Sve sto je >70% je dobro za vakcinu.

[Jozef K.]

Koliko kapiram JNJ je na bazi adenovirusa. Samo što je jedan šot. Pošto sam preležao, meni deluje da je to najbolje za mene. Da se tamo krajem godine roknem jednim šotom da se malo pobudi imuni sistem, ako se pokaže da imunitet opada, mada mislim da on traje nekoliko godina sigurno. Ne znam da li dobro rezonujem?

[Moracikus]

[vememah]

Quote

 

“The nightmare scenario that was described in the media in the spring with a vaccine only working a month or two is, I think, out of the window,” Moderna CEO Stephane Bancel said at an event organised by financial services group Oddo BHF.

“The antibody decay generated by the vaccine in humans goes down very slowly (...) We believe there will be protection potentially for a couple of years.”

 

https://www.reuters.com/article/us-health-coronavirus-moderna-vaccine-idUSKBN29C0YK

[vememah]

 

Quote

 

Covid-19 immunity likely lasts for years

A new study shows immune cells primed to fight the coronavirus should persist for a long time after someone is vaccinated or recovers from infection.

by 

• Neel V. Patel

January 6, 2021

Covid-19 patients who recovered from the disease still have robust immunity from the coronavirus eight months after infection, according to a new study. The result is an encouraging sign that the authors interpret to mean immunity to the virus probably lasts for many years, and it should alleviate fears that the covid-19 vaccine would require repeated booster shots to protect against the disease and finally get the pandemic under control.

“There was a lot of concern originally that this virus might not induce much memory,” says Shane Crotty, a researcher at the La Jolla Institute for Immunology in California and a coauthor of the new paper. “Instead, the immune memory looks quite good.”

The study, published January 6 in Science, contrasts with earlier findings that suggested covid-19 immunity could be short-lived, putting millions who’ve already recovered at risk of reinfection. That predicament wouldn’t have been a total surprise, since infection by other coronaviruses generates antibodies that fade fairly quickly. But the new study suggests reinfection should only be a problem for a very small percentage of people who’ve developed immunity—whether through an initial infection or by vaccination. 

In fact, the new study does show that a small number of recovered people do not have long-lasting immunity. But vaccination ought to offset that problem by ensuring herd immunity in the larger population. 

The new paper studied blood samples from 185 men and women who had recovered from covid-19—most from a mild infection, although 7% were hospitalized. Each person provided at least one blood sample between six days and eight months after their initial symptoms, and 43 of the samples were taken after six months. The team that ran the investigation measured the levels of several immunological agents that work together to prevent reinfection: antibodies (which tag a pathogen for destruction by the immune system or neutralize its activity), B cells (which make antibodies), and T cells (which kill infected cells). 

The researchers found that antibodies in the body declined moderately after eight months, although levels varied wildly between individuals. But T-cell numbers declined only modestly, and B-cell numbers held steady and sometimes inexplicably grew. That means that despite decreases in free-flowing antibodies, the components that can restart antibody production and coordinate an attack against the coronavirus stick around at pretty high levels. Crotty adds that the same mechanisms that lead to immune memory after infection also form the basis for immunity after vaccination, so the same trends ought to hold for vaccinated people as well. 

And while immunity to other coronaviruses has been less than stellar, it’s worth looking at what happens in people who recovered from SARS, a close cousin of the virus that causes covid-19. A study published in August showed that T cells specific to SARS can remain in the blood for at least 17 years, bolstering hopes that covid-19 immunity could last for decades.

The new study isn’t perfect. It would have been better to collect multiple blood samples from every participant. “Immunity varies from person to person, and uncommon individuals with weak immune memory still may be susceptible to reinfection,” Crotty cautions. And we can’t make any firm conclusions about covid-19 immunity until years have passed—it’s simply too early. Nonetheless, this latest result is a good indication that if the vaccination rollout goes well (a big if), we might soon be able to put the pandemic behind us.

https://www.technologyreview.com/2021/01/06/1015822/covid-19-immunity-likely-lasts-for-years/

[vememah]

Quote

Since the start of the pandemic, the figure that many epidemiologists have offered has been 60 to 70 percent. That range is still cited by the World Health Organization and is often repeated during discussions of the future course of the disease.

Although it is impossible to know with certainty what the limit will be until we reach it and transmission stops, having a good estimate is important: It gives Americans a sense of when we can hope to breathe freely again.

Recently, a figure to whom millions of Americans look for guidance — Dr. Anthony S. Fauci, an adviser to both the Trump administration and the incoming Biden administration — has begun incrementally raising his herd-immunity estimate.

In the pandemic’s early days, Dr. Fauci tended to cite the same 60 to 70 percent estimate that most experts did. About a month ago, he began saying “70, 75 percent” in television interviews. And last week, in an interview with CNBC News, he said “75, 80, 85 percent” and “75 to 80-plus percent.”

In a telephone interview the next day, Dr. Fauci acknowledged that he had slowly but deliberately been moving the goal posts. He is doing so, he said, partly based on new science, and partly on his gut feeling that the country is finally ready to hear what he really thinks.

Hard as it may be to hear, he said, he believes that it may take close to 90 percent immunity to bring the virus to a halt — almost as much as is needed to stop a measles outbreak.

Asked about Dr. Fauci’s conclusions, prominent epidemiologists said that he might be proven right. The early range of 60 to 70 percent was almost undoubtedly too low, they said, and the virus is becoming more transmissible, so it will take greater herd immunity to stop it.

https://www.nytimes.com/2020/12/24/health/herd-immunity-covid-coronavirus.html

 

Quote

Prof. Gabi Barbash, former director-general of the Health Ministry [of Israel], tells Channel 12 News that health experts around the world no longer believe that 60%-70% immunity in the population will be enough to achieve herd immunity and end the pandemic.

Due to the new variants of the coronavirus that are more contagious than the previous forms, it is now believed that immunity of some 90% will be needed to effectively vanquish the disease.

https://www.timesofisrael.com/liveblog_entry/health-expert-says-60-70-population-immunity-no-longer-enough-to-end-pandemic/

 

Quote

With the discovery of new, more contagious strains of the Covid-19 virus in Britain and South Africa, it may now be important for more Singaporeans to get vaccinated against the coronavirus, said a health expert here.

Professor Teo Yik Ying, dean of the Saw Swee Hock School of Public Health at the National University of Singapore, said yesterday: "This is the only way we can continue to ensure that the community as a whole is protected."

This means that instead of aiming to get 80 per cent of the population here vaccinated against Covid-19, "we may now be looking at 90 per cent, or even higher", Prof Teo said in a video interview with The Straits Times on its daily online talk show, The Big Story.

The Health Ministry's chief health scientist, Professor Tan Chorh Chuan, previously told The Straits Times that at least 80 per cent of the population would have to be vaccinated to achieve herd immunity against Covid-19.

https://www.straitstimes.com/singapore/new-strains-more-people-may-need-to-be-vaccinated

Edited January 13, 2021 by vememah

[gone fishing]

[Dankan Ajdaho]

https://nova.rs/magazin/zdravlje/konacno-se-zna-zasto-imunitet-poludi-od-korone/

[vememah]

Quote

 

Russia will submit a formal application to the European Union next month for approval of its Sputnik V coronavirus vaccine, the head of Russia’s sovereign wealth fund said on Thursday.

Peer-reviewed results of the vaccine would be released shortly and would demonstrate its high efficacy, fund chief Kirill Dmitriev said in an interview at the Reuters Next conference.

He said Sputnik V would be produced in seven countries. He added that regulators in nine countries are expected to approve the vaccine for domestic use this month. It has already been approved in Argentina, Belarus, Serbia and elsewhere.

Russia, which has the world’s fourth-highest number of COVID-19 cases, plans to begin mass vaccinations next week.

 

https://www.reuters.com/article/us-health-coronavirus-russia-dmitriev/russia-to-submit-sputnik-v-vaccine-for-eu-approval-says-rdif-chief-idUSKBN29J1DX

[Moracikus]

https://fortune.com/2021/01/13/johnson-and-johnson-vaccine-covid-efficacy/amp/?__twitter_impression=true

Po ovome clanku naslucujem JNJ na 70-80 %.

21.1 ce valjda saznati tacnu cifru na osnovu broja zarazenih

[Sludge Factory]

Neko mi danas rece kako je Gligic protiv fajzerove vakcine jer je GMO. Kao, ne znamo mi kako ce GMO vakcina da se ponasa na duze staze, za neku godinu, sta moze da napravi u organizmu. WTF? Kolko god da citam, nisam bas razumeo da je fajzeorva vakcina neki GMO virus. Da ne ulazimo sad u to da li je i kako bilo sta GMO stetno na bilo koji nacin. 

Edited January 14, 2021 by Sludge Factory

[vememah]

Lupetanje, Gligićka nije spominjala GMO. Ima ovde šta je rekla.

https://www.b92.net/zdravlje/vesti.php?yyyy=2020&mm=12&dd=14&nav_id=1780491

[vememah]

 

 

 

 

[Dankan Ajdaho]

https://www.b92.net/zdravlje/vesti.php?yyyy=2021&mm=01&dd=13&nav_id=1794314